4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid

Base Information

• Chemical Name: 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid
• CAS No.: 1335246-19-9
• Molecular Formula: C₁₈H₁₃F₃N₂O₃
• Molecular Weight: 362.308

Synonyms:4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid

Chemical Property of 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid

Chemical Property:

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Technology Process of 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid

There total 2 articles about 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4,4-trifluoro-1-(3-methoxyphenyl)butane-1,3-dione (57965-21-6) + 4-Hydrazinobenzoic acid (619-67-0) → 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid (1335246-19-9)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 20h; regioselective reaction; Reflux;

DOI:10.1016/j.ejmech.2011.05.024

Reference yield:

1-(3-Methoxyphenyl)ethanone (586-37-8) → 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid (1335246-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / -5 - 0 °C / Inert atmosphere

1.2: 6 h / -5 - 20 °C / Inert atmosphere

1.3: pH 6 / Cooling with ice

2.1: hydrogenchloride / ethanol; water / 20 h / Reflux

With hydrogenchloride; sodium hydride; In tetrahydrofuran; ethanol; water; 1.2: Claisen condensation;

DOI:10.1016/j.ejmech.2011.05.024

Reference yield:

4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid (1335246-19-9) + [11C]methyl triflate (145577-00-0) → [(11)C]methyl 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoate (1335246-28-0)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 80 ℃; for 0.05h;

DOI:10.1016/j.ejmech.2011.05.024

upstream raw materials:

4,4,4-trifluoro-1-(3-methoxyphenyl)butane-1,3-dione

4-Hydrazinobenzoic acid

1-(3-Methoxyphenyl)ethanone

Downstream raw materials:

[⁽¹¹⁾C]methyl 4-(5-(3-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoate

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