(2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

Base Information

Chemical Name:(2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester
CAS No.:443149-78-8
Molecular Formula:C₂₆H₃₅N₃O₅
Molecular Weight:469.581
Hs Code.:

Synonyms:(2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

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Chemical Property of (2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

Chemical Property:

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Technology Process of (2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

There total 8 articles about (2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₄₂N₂O₆

: 443149-78-8
(2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

Guidance literature:: With O-Trimethylsilylhydroxylamine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jo0110698

Reference yield:

: 35373-92-3
L-phenylalanine methylamide

: 443149-78-8
(2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / tetrabutylammonium iodide; potassium carbonate / dimethylformamide / 144 h / 60 °C

2: 92 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 0.5 h / 20 °C / pH 10

3: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

4: N-methylmorpholine / tetrahydrofuran / 0.5 h / -10 °C

5: 501 mg / O-(trimethylsilyl)hydroxylamine / tetrahydrofuran / 4 h / 20 °C

With 4-methyl-morpholine; O-Trimethylsilylhydroxylamine; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698

Reference yield:

: 144287-83-2
(R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)-5-methylhexanoate

: 443149-78-8
(2R)-(2-hydroxycarbamoylmethyl-4-methylpentyl)-(1S)-(1-methylcarbamoyl-2-phenylethyl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / lithium borohydride; MeOH / diethyl ether / 1.5 h / 0 °C

2: 89 percent / PPh₃; CBr₄ / CH₂Cl₂ / 2 h / 20 °C

3: 42 percent / tetrabutylammonium iodide; potassium carbonate / dimethylformamide / 144 h / 60 °C

4: 92 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 0.5 h / 20 °C / pH 10

5: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

6: N-methylmorpholine / tetrahydrofuran / 0.5 h / -10 °C

7: 501 mg / O-(trimethylsilyl)hydroxylamine / tetrahydrofuran / 4 h / 20 °C

With 4-methyl-morpholine; methanol; lithium borohydride; carbon tetrabromide; O-Trimethylsilylhydroxylamine; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0110698