L-Phenylalanine methylamide

Base Information

• Chemical Name: L-Phenylalanine methylamide
• CAS No.: 35373-92-3
• Molecular Formula: C10H14 N2 O
• Molecular Weight: 178.234
• Hs Code.: 2924299090
• Mol file: 35373-92-3.mol

Synonyms:Benzenepropanamide,a-amino-N-methyl-, (S)-;(2S)-2-Amino-N-methyl-3-phenylpropanamide; (S)-Phenylalanine N-methylamide;(S)-Phenylalanine methylamide; L-Phenylalanine methylamide

Chemical Property of L-Phenylalanine methylamide

Chemical Property:

• Melting Point: 58-60 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 379.2±35.0 °C(Predicted)
• PKA: 15.58±0.46(Predicted)
• PSA: 55.12000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 1.39360

Purity/Quality:

98.5% ^*data from raw suppliers

N-methyl-L-phenylalaninamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of L-Phenylalanine methylamide

There total 34 articles about L-Phenylalanine methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + methylamine (74-89-5) → L-phenylalanine methylamide (35373-92-3)

Guidance literature:

In ethanol; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.3762/bjoc.8.160

Reference yield: 99.0%

H-Phe-OEt (3081-24-1) + methylamine (74-89-5) → L-phenylalanine methylamide (35373-92-3)

Guidance literature:

In water; for 0.5h;

DOI:10.1016/S0040-4020(01)81979-7

Reference yield: 97.0%

(L)-phenylalanine ethyl ester hydrochloride (3182-93-2) + methylamine (74-89-5) → L-phenylalanine methylamide (35373-92-3)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1021/acs.orglett.8b03551

upstream raw materials:

(S)-N-Benzyloxycarbonyl-phenylalanine-N'-methylamide

N-(t-butoxycarbonyl)-L-phenylalanine methylamide

(3S,4R)-1-methyl-4-phenyl-3-[(4S)-4-phenyl-2-oxo-1,3-oxazolidin-3-yl]-azetidin-2-one

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

N-(tert-butoxycarbonyl)isoleucinylphenylalanine methylamide

(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

(1S,2S,3S)-2-Benzyloxymethyl-3-hydroxymethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Refernces

• 1、 Bauer, Felix,Breit, Bernhard,Khosravi, Hormoz,Panahi, Farhad. "Asymmetric hydroalkylation of alkynes and allenes with imidazolidinone derivatives: α-alkenylation of α-amino acids". . p. 7388 - 7392. Retrieved 2021/06/09.
• 2、 Nacsa, Eric D.,MacMillan, David W. C.. "Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols". supporting information. p. 3322 - 3330. Retrieved 2018/03/13.