3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

Base Information

Chemical Name:3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester
CAS No.:142545-26-4
Molecular Formula:C₁₉H₃₁NO₅Si
Molecular Weight:381.544
Hs Code.:

Synonyms:3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

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Chemical Property of 3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

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Technology Process of 3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

There total 5 articles about 3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 192517-47-8
methyl (3S)-3-[[(benzyloxy)carbonyl]amino]-4-hydroxybutanoate

: 142545-26-4
3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 40 ℃; for 2h;
DOI:10.1016/S0040-4020(01)92199-4

Reference yield:

: 2177-62-0
β-methyl L-aspartate

: 142545-26-4
3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / potassium carbonate / H₂O; diethyl ether / 4 h / 20 °C

2: 4-methylmorpholine / tetrahydrofuran / -10 °C

3: 2.33 g / NaBH₄ / tetrahydrofuran

4: 85 percent / imidazole / dimethylformamide / 20 °C

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300199

Reference yield:

: 3160-47-2
N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

: 142545-26-4
3(S)-Benzyloxycarbonylamino-4-tert-butyldimethylsilyloxypropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methylmorpholine / tetrahydrofuran / -10 °C

2: 2.33 g / NaBH₄ / tetrahydrofuran

3: 85 percent / imidazole / dimethylformamide / 20 °C

With 4-methyl-morpholine; 1H-imidazole; sodium tetrahydroborate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300199