2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

Base Information

Chemical Name:2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone
CAS No.:719288-26-3
Molecular Formula:C₂₄H₂₉FN₂O₄
Molecular Weight:428.504
Hs Code.:

Synonyms:2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

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Chemical Property of 2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

Chemical Property:

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Technology Process of 2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

There total 3 articles about 2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 719288-25-2
1-(2-(benzyloxy)-4-fluorophenyl)-2-bromoethan-1-one

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 719288-26-3
2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

Reference yield:

: 106245-03-8
1-(2-(benzyloxy)-4-fluorophenyl)ethan-1-one

: 719288-26-3
2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1: phenyl-trimethyl-ammonium perbromide / tetrahydrofuran / 0.75 h / 20 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

With phenyl-trimethyl-ammonium perbromide; potassium carbonate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);

Reference yield:

: 100-39-0
benzyl bromide

: 719288-26-3
2'-(benzyloxy)-2-[4-(tert-butoxycarbonyl)piperazin-1-yl]-4'-fluoroacetophenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide)

1.2: 0.08 h / 20 °C

1.3: 18 h

2.1: phenyl-trimethyl-ammonium perbromide / tetrahydrofuran / 0.75 h / 20 °C

3.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

With phenyl-trimethyl-ammonium perbromide; potassium carbonate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);