(1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

Base Information

Chemical Name:(1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine
CAS No.:1231217-53-0
Molecular Formula:C₃₀H₃₅NO₃
Molecular Weight:457.613
Hs Code.:

Synonyms:(1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

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Chemical Property of (1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

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Technology Process of (1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

There total 2 articles about (1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1231217-48-3
(2S,3S,4S,5S)-1-(tertbutoxycarbonyl)-3,4-bis-(benzyloxy)-2-((benzyloxy)methyl)-5-(3,3-oxobutyl)pyrrolidine

: 1231217-53-0
(1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

Guidance literature:: (2S,3S,4S,5S)-1-(tertbutoxycarbonyl)-3,4-bis-(benzyloxy)-2-((benzyloxy)methyl)-5-(3,3-oxobutyl)pyrrolidine; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h; diastereoselective reaction;
DOI:10.1055/s-0029-1219540

Reference yield:

: 917-64-6
methyl magnesium iodide

: 1231217-55-2
(3R,5S,6S,7S,7aS)-6,7-bis(benzyloxy)-5-((benzyloxy)methyl)-hexahydro-1H-pyrrolizine-3-carbonitrile

: 1231217-53-0
(1S,2S,3S,5S,7aS)-1,2-bis-(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

: 1231217-47-2
(1S,2S,3S,5S,7aS)-1,2-bis(benzyloxy)-3-((benzyloxy)methyl)-5-methyl-pyrrolizidine

Guidance literature:: (3R,5S,6S,7S,7aS)-6,7-bis(benzyloxy)-5-((benzyloxy)methyl)-hexahydro-1H-pyrrolizine-3-carbonitrile; With silver tetrafluoroborate; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

methyl magnesium iodide; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h; optical yield given as %de; Inert atmosphere;
DOI:10.1055/s-0029-1219540