4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Base Information

Chemical Name:4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid
CAS No.:103124-12-5
Molecular Formula:C₁₇H₁₇F₂NO₅
Molecular Weight:353.322
Hs Code.:

Synonyms:4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

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Chemical Property of 4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

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Technology Process of 4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

There total 4 articles about 4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 400884-04-0
3-(2-cyanoethyl) 5-methyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

: 103124-12-5
4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 6h;
DOI:10.1021/jo0104025

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 103124-12-5
4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 53.2 percent / piperidine; acetic acid / propan-2-ol / 6 h / 20 °C

2: 69 percent / ethanol / 6 h / Heating

3: 86 percent / KOH / ethanol / 6 h / 20 °C

With piperidine; potassium hydroxide; acetic acid; In ethanol; isopropyl alcohol;
DOI:10.1021/jo0104025

Reference yield:

: 400884-01-7
2-[2-(difluoromethoxy)benzylidene]methyl acetoacetate

: 103124-12-5
4-[2-(difluoromethoxy)phenyl]-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / ethanol / 6 h / Heating

2: 86 percent / KOH / ethanol / 6 h / 20 °C

With potassium hydroxide; In ethanol;
DOI:10.1021/jo0104025