N⁶-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine

Base Information

• Chemical Name: N⁶-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine
• CAS No.: 153235-85-9
• Molecular Formula: C₃₂H₃₆N₅O₅P
• Molecular Weight: 601.642
• Mol file: 153235-85-9.mol

Synonyms:N⁶-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine

Chemical Property of N⁶-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine

There total 1 articles about N⁶-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester (116384-53-3) + mono-4-methoxytrityl chloride (14470-28-1) → N6-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine (153235-85-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jm050641a

Reference yield:

N6-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine (153235-85-9) + trimethylsilyl bromide (2857-97-8) → C34H44N5O5PSi2

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃; for 16h;

DOI:10.1021/jm050641a

Reference yield:

N6-4-monomethoxytrityl-9-[2-(diethylphosphonylmethoxy)ethyl]adenine (153235-85-9) → C28H26Cl2N5O3P

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetonitrile / 16 h / 20 °C

2: PCl₅ / CH₂Cl₂ / 2.5 h / 20 °C

With pyridine; phosphorus pentachloride; In dichloromethane; acetonitrile;

DOI:10.1021/jm050641a

upstream raw materials:

[[2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid diethyl ester

mono-4-methoxytrityl chloride

Downstream raw materials:

N⁶-4-monomethoxytrityl-9-[2-(cycloSal-phosphonylmethoxy)ethyl]adenine

N⁶-4-monomethoxytrityl-9-{2-[(3-methyl-cycloSal)phosphonylmethoxy]ethyl}adenine

N⁶-4-monomethoxytrityl-9-{2-[(3-tert-butyl-cycloSal)phosphonylmethoxy]ethyl}adenine

N⁶-4-monomethoxytrityl-9-{2-[(3,5-di-tert-butyl-cycloSal)phosphonylmethoxy]ethyl}adenine