ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

Base Information

• Chemical Name: ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate
• CAS No.: 1453861-64-7
• Molecular Formula: C₃₂H₃₅ClO₇S
• Molecular Weight: 599.145
• Mol file: 1453861-64-7.mol

Synonyms:ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

Chemical Property of ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

There total 8 articles about ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate (928149-12-6) + ethyl 2-(3-(4-((2'-chloro-4'-hydroxy-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate (1453861-55-6) → ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate (1453861-64-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate (1453862-20-8) → ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate (1453861-64-7)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 8 h / 80 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 115 °C / Microwave irradiation

4: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

ethyl 2-(3-(4-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)phenyl)oxetan-3-yl)acetate (1453862-21-9) → ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate (1453861-64-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 115 °C / Microwave irradiation

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate

ethyl 2-(3-(4-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)phenyl)oxetan-3-yl)acetate

(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate

ethyl 2-(3-(4-((2'-chloro-4'-hydroxy-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

Downstream raw materials:

2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid