ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate

Base Information

• Chemical Name: ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate
• CAS No.: 1453862-20-8
• Molecular Formula: C₂₀H₂₁BrO₄
• Molecular Weight: 405.288
• Mol file: 1453862-20-8.mol

Synonyms:ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate

Chemical Property of ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate

There total 2 articles about ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

meta-bromobenzyl bromide (823-78-9) + ethyl 2-(3-(4-hydroxyphenyl)oxetan-3-yl)acetate (1449228-41-4) → ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate (1453862-20-8)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

ethyl 2-(oxetan-3-ylidene)acetate (922500-91-2) → ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate (1453862-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium hydroxide / 1,4-dioxane / 6 h

2: caesium carbonate / tetrahydrofuran / 0 - 20 °C

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane;

Reference yield: 97.0%

ethyl 2-(3-(4-((3-bromobenzyl)oxy)phenyl)oxetan-3-yl)acetate (1453862-20-8) + bispinacolatodiborane → ethyl 2-(3-(4-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)phenyl)oxetan-3-yl)acetate (1453862-21-9)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 8h;

upstream raw materials:

meta-bromobenzyl bromide

ethyl 2-(3-(4-hydroxyphenyl)oxetan-3-yl)acetate

ethyl 2-(oxetan-3-ylidene)acetate

Downstream raw materials:

ethyl 2-(3-(4-((4'-(methylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

2-(3-(4-((4'-(methylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid

ethyl 2-(3-(4-((4'-(butylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

2-(3-(4-((4'-(butylthio)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid