4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

Base Information

Chemical Name:4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin
CAS No.:1357099-11-6
Molecular Formula:C₄₂H₄₁NO₁₃
Molecular Weight:767.786
Hs Code.:

Synonyms:4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

Suppliers and Price of 4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

There total 5 articles about 4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1357099-41-2
(E)-2-(3-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetic acid

: 155252-35-0
4β-amino-4-deoxypodophyllotoxin

: 1357099-11-6
4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2011.11.024

Reference yield:

: 1197288-81-5
(E)-3-(3-hydroxyphenyl)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one

: 1357099-11-6
4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With lithium hydroxide monohydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.11.024

Reference yield:

: 1357099-34-3
(E)-ethyl-2-(3-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)phenoxy)acetate

: 1357099-11-6
4β-[2-(3-[(E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propenyl]phenoxy)acetamido]-4-deoxyodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.11.024