155252-35-0

Upstream product

• 197016-28-7 (5R,5aR,8aS)-9-Azido-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 748151-22-6 4-β-(2''-chloroacetamido)podophyllotoxin 
• 4375-07-9 epipodophyllotoxin 
• 908355-89-5 Methanesulfonic acid (5R,5aR,8aR,9R)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl ester 
• 518-28-5 podofilox 
• 106636-74-2 4β-bromo-4-desoxypodophyllotoxin 
• 155252-34-9 4β-azido-4-deoxypodophyllotoxin 

Downstream Products

• 1061717-11-0 4β-((1-(benzo[1,3]dioxol-5-ylmethyl)-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1061717-14-3 4β-((2-methyl-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1061717-19-8 4β-((6-methoxy-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1061717-17-6 4β-((5-methoxy-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1061717-16-5 4β-((6-fluoro-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1061717-12-1 4β-((5-bromo-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1000206-52-9 4β-((1-(4-chlorobenzyl)-indol-3-yl)-glyoxylamide)-4-desoxypodophyllotoxin 
• 1244966-36-6 C₃₁H₂₈N₂O₁₂ 

Relevant academic research and scientific papers

Click chemistry-assisted synthesis of triazolo linked podophyllotoxin conjugates as tubulin polymerization inhibitors

A series of new triazolo linked 4β-amidopodophyllotoxin conjugates (9a-l) were synthesized using click chemistry and evaluated for their antitumor activity against four human cancer cell lines. Among them, two compounds (9c and 9j) showed significant anti

Design and synthesis of novel podophyllotoxins hybrids and the effects of different functional groups on cytotoxicity

Development of novel anticancer therapeutic candidates is one of the key challenges in medicinal chemistry. Podophyllotoxin and its derivatives, as a potent cytotoxic agent, have been at the center of extensive chemical amendment and pharmacological inves

Synthesis and Anticancer Activity of Podophyllotoxin Derivatives

Two series of podophyllotoxin derivatives were synthesized by addition of a 4β-sulfanilamide to or substitution of a 4β-amide into podophyllotoxin. Their cytotoxicities were evaluated against four human cancer cell lines (A549, HeLa, MCF-7, and PC-3). Inv

Synthesis and Cytotoxicity of Heterocyclic Amine Derivatives of Podophyllotoxin

A series of amine podophyllotoxin derivatives was designed and synthesized by aldehydes reacting with 4β-amino-desoxypodophyllotoxin or 4′-demethyldesoxypodophyllotoxin. The MTT assay was used to test the cytotoxic activity of 11 target compounds on HeLa

4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer

Topoisomerases (topo-I and topo-II) have occupied a significant role in DNA replication, transcription, and are a promising set of antitumor targets. In the present approach, a series of new 4β-amidotriazole linked podophyllotoxin derivatives (10a-i and 1

Podophyllotoxin compound containing 1,2,4-triazone structure, and application thereof

The invention discloses a podophyllotoxin compound containing a 1,2,4-triazone structure, and an application thereof. The compound has a structure represented by general formula (I). Podophyllotoxin derivatives containing 1,2,4-triazone, represented by th

Synthesis and evaluation of new podophyllotoxin derivatives with in vitro anticancer activity

A series of novel podophyllotoxin derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested against three tumor cell lines (HeLa, K562, and K562/A02). Most of the derivatives (IC50 = 1-20 μM) were found

Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions

Spin-labeled podophyllotoxins have elicited widespread interest due to their far superior antitumor activity compared to podophyllotoxin. To extend our prior studies in this research area, we synthesized a new generation of spin-labeled podophyllotoxin an

Synthesis and biological evaluation of novel podophyllotoxin analogs as antitumor agents

A series of 4β N-indole-substituted podophyllotoxin derivatives were synthesized. Nine target compounds were evaluated against human cancer cell lines (HeLa, K562, and K562/A02) using MTT assay including three imine derivatives 8, 9, and 10in vitro. The result showed that the three compounds had higher antitumor activity than their reduced forms. Among them, compounds 8, 9, 11, and 16 were superior to the positive control VP-16.

Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents

Cancer multidrug resistance (MDR) is a common cause of treatment failure in cancer patients. Increased expression of permeability glycoprotein (P-gp), which is also known as MDR-1, is the main cause of multidrug resistance. Podophyllotoxin derivatives hold great promise in the battle to overcome multidrug resistance, as they can induce cytotoxicity through multiple mechanisms. Here, we synthesized sixteen novel podophyllotoxin derivatives and evaluated their cytotoxicities in human cancer cell lines, HeLa, K562 and K562/A02. Some of these compounds were more potent than etoposide, a clinically relevant inhibitor of DNA repair enzymes. In particular, compound 5p exhibited the most potent activity toward drug-resistant K562/A02 cells, as it robustly inhibited tumor cell proliferation and induced apoptosis. Furthermore, preliminary investigation suggested that 5p inhibited the expression of MDR-1 in K562/A02 cells more effectively than etoposide.