(6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Base Information

Chemical Name:(6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine
CAS No.:1309462-11-0
Molecular Formula:C₂₅H₂₅NO
Molecular Weight:355.48
Hs Code.:

Synonyms:(6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

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Chemical Property of (6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

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Technology Process of (6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

There total 4 articles about (6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309462-03-0
(1S,2S)-2-(benzyl(3-methoxybenzyl)amino)-1,2,3,4-tetrahydronaphthalen-1-ol

: 1309462-12-1
(6aS,12bS)-6-benzyl-3-methoxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

: 1309462-11-0
(6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: With iron (III) chloride hexahydrate; In dichloromethane; at 60 - 65 ℃; for 24h; chemoselective reaction;
DOI:10.1021/ol2008236

Reference yield:

: 573-57-9
1,4-epoxy-1,4-dihydronaphthalene

: 1309462-12-1
(6aS,12bS)-6-benzyl-3-methoxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

: 1309462-11-0
(6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: Multi-step reaction with 3 steps

1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; C₃₂H₄₂FeP₂⁽¹⁺⁾ / tetrahydrofuran / 24 h / 60 °C / Inert atmosphere

2: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux

3: iron (III) chloride hexahydrate / dichloromethane / 24 h / 60 - 65 °C

With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; iron (III) chloride hexahydrate; C₃₂H₄₂FeP₂⁽¹⁺⁾; sodium acetate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; dichloromethane; water; 3: Friedel Crafts alkylation;
DOI:10.1021/ol2008236

Reference yield:

: 134240-37-2
m-methoxydibenzylamine

: 1309462-12-1
(6aS,12bS)-6-benzyl-3-methoxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

: 1309462-11-0
(6aS,12bS)-6-(3-methoxybenzyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: Multi-step reaction with 3 steps

1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; C₃₂H₄₂FeP₂⁽¹⁺⁾ / tetrahydrofuran / 24 h / 60 °C / Inert atmosphere

2: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux

3: iron (III) chloride hexahydrate / dichloromethane / 24 h / 60 - 65 °C

With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; iron (III) chloride hexahydrate; C₃₂H₄₂FeP₂⁽¹⁺⁾; sodium acetate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; dichloromethane; water; 3: Friedel Crafts alkylation;
DOI:10.1021/ol2008236