N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

Base Information

Chemical Name:N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide
CAS No.:1439935-94-0
Molecular Formula:C₂₂H₁₈N₄O₃S
Molecular Weight:418.476
Hs Code.:

Synonyms:N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

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Chemical Property of N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

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Technology Process of N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

There total 4 articles about N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 13466-38-1
5-bromopyridin-2-ol

: 1439935-97-3
N-(4-(4-hydroxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

: 1439935-94-0
N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

Guidance literature:: N-(4-(4-hydroxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide; With copper; caesium carbonate; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 1h;

5-bromopyridin-2-ol; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

Reference yield:

: 91060-92-3
1-(4-hydroxy-2,6-dimethylphenyl)ethanone

: 1439935-94-0
N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammomium bromide / acetonitrile / 1.5 h / 20 °C

2.1: ethanol / 2 h / Reflux

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: caesium carbonate; copper / N,N-dimethyl-formamide / 1 h / 80 - 90 °C

4.2: 24 h / 100 °C

With tetrabutylammomium bromide; copper; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1439935-95-1
2-bromo-1-(4-hydroxy-2,6-dimethylphenyl)ethanone

: 1439935-94-0
N-{4-(4-((6-hydroxypyridin-3-yl)oxy)-2,6-dimethylphenyl)thiazol-2-yl}isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / Reflux

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: caesium carbonate; copper / N,N-dimethyl-formamide / 1 h / 80 - 90 °C

3.2: 24 h / 100 °C

With copper; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;