91060-92-3

Basic information

• Product Name: 1-(4-Hydroxy-2,6-diMethylphenyl)ethanone
• Synonyms: 1-(4-Hydroxy-2,6-diMethylphenyl)ethanone
• CAS NO: 91060-92-3
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• EINECS: -0
• Mol File: 91060-92-3.mol

Chemical Properties

• Melting Point: 150-151 °C
• Boiling Point: 317.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.080±0.06 g/cm3(Predicted)
• PKA: 8.41±0.23(Predicted)
• CAS DataBase Reference: 1-(4-Hydroxy-2,6-diMethylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Hydroxy-2,6-diMethylphenyl)ethanone(91060-92-3)
• EPA Substance Registry System: 1-(4-Hydroxy-2,6-diMethylphenyl)ethanone(91060-92-3)

Safety Data

• Hazardous Substances Data: 91060-92-3(Hazardous Substances Data)

Usage

Preparation

Preparation by diazotization of 4-amino-2,6-dimethylaceto-phenone, followed by hydrolysis of the obtained diazonium salt (68%).

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 
• 2050-45-5 N-acetyl-3,5-dimethylaniline 
• 100923-73-7 N-(4-acetyl-3,5-dimethylphenyl)acetamide 
• 108-68-9 3,5-Dimethylphenol 
• 83759-88-0 1-(4-amino-2,6 dimethylphenyl)ethanone 

Downstream Products

• 1310320-06-9 2-bromo-1-(4-methoxy-2,6-dimethylphenyl)ethanone 
• 1334921-86-6 2-bromo-1-(4-ethoxy-2,6-dimethylphenyl)ethanone 
• 1216250-42-8 4-(4-methoxy-2,6-dimethylphenyl)thiazol-2-amine 
• 1334921-87-7 4-(4-ethoxy-2,6-dimethylphenyl)thiazol-2-amine 
• 60999-76-0 1-(4-methoxy-2,6-dimethylphenyl)ethanone 
• 1216222-72-8 1-(4-ethoxy-2,6-dimethylphenyl)ethanone 
• 1334921-90-2 4-acetyl-3,5-dimethylphenyl trifluoromethanesulfonate 
• 1439936-46-5 1-{4-(4-(3-methoxypropoxy)phenoxy)-2,6-dimethylphenyl}ethanone 
• 1439936-41-0 2-bromo-1-{4-((5-methoxypyridin-2-yl)oxy)-2,6-dimethylphenyl}ethanone 
• 1439936-35-2 1-(4-(4-isopropoxyphenoxy)-2,6-dimethylphenyl)ethanone 
• 1439936-07-8 1-{4-((5-methoxypyrimidin-2-yl)oxy)-2,6-dimethylphenyl}ethanone 
• 1439936-31-8 1-{4-((5-methoxypyrazin-2-yl)oxy)-2,6-dimethylphenyl}ethanone 
• 1439936-03-4 C₁₄H₁₄N₂O₂ 
• 1439935-99-5 1-(2,6-dimethyl-4-(pyrimidin-2-yloxy)phenyl)ethanone 

Relevant articles and documents

Aerobic intramolecular carbon-hydrogen bond oxidation promoted by Cu(i) complexes

The oxidation of C-H bonds by copper centres in enzymes with molecular oxygen takes place in nature under ambient conditions. Herein we report a similar transformation in which under ambient pressure and temperature (1 atm, 25 °C) the complex TpMsCu(THF)

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.

P-HYDROXY PHENONE DERIVATIVES AND THE USE THEREOF

p-Hydroxy phenone derivatives of the general formula I STR1 where R 1, R 2 and R 3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R 1, R 2 and R 3 are not all H,R 4 and R 5 are identical or different and are H, C 1-C 4-alkyl, or OR 6, but R 4 and R 5 are not both H,X is a--CH=CH--,--CH. sub.2 CH 2 or--CH. sub.2--bridge,Y is a straight-chain or branched, saturated or unsaturated C 1-C 4 bridge, and Z is NR 6 R 7, where R 6 and R 7 are, independently of one another, hydrogen or C 1-4-alkyl, or Z is a 5-or 6-membered ring with a nitrogen atom in the 1 position and, where appropriate, additionally a second N atom or an O or S atom, the second N atom being substituted by R 7, as well as the physiologically tolerated salts thereof,are used to prepare drugs antiarrhythmic of Vaughan-Williams class III.