3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

Base Information

Chemical Name:3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester
CAS No.:223923-92-0
Molecular Formula:C₄₉H₇₅N₅O₁₃
Molecular Weight:942.16
Hs Code.:

3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-<i>tert</i>-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

Synonyms:3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

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Chemical Property of 3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

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Technology Process of 3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

There total 10 articles about 3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134440-96-3
(2S,3R)-N-tert-butoxycarbonyl-2-methyl-3-amino-4-hydroxy methyl butanoate

: 223923-92-0
3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 123 mg / oxalyl chloride / CH₂Cl₂ / 1 h / -78 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C (15 min), 0 deg C (30 min), 2.) THF, -> room temp., 20 h

3: 98 percent / aq. LiOH / tetrahydrofuran / 68 h / Ambient temperature

4: 88 percent / DCC, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

5: 81 percent Turnov_. / DMAP, diisopropylethylamine / acetonitrile / 90 h / Ambient temperature

With dmap; lithium hydroxide; n-butyllithium; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo982145i

Reference yield:

: 134440-97-4
(2R,3S)-2-(tert-butoxycarbonyl)amino-3-methoxycarbonyl-3-methylbutanal

: 223923-92-0
3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C (15 min), 0 deg C (30 min), 2.) THF, -> room temp., 20 h

2: 98 percent / aq. LiOH / tetrahydrofuran / 68 h / Ambient temperature

3: 88 percent / DCC, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

4: 81 percent Turnov_. / DMAP, diisopropylethylamine / acetonitrile / 90 h / Ambient temperature

With dmap; lithium hydroxide; n-butyllithium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo982145i

Reference yield:

: 82706-51-2
E-(2S,3R)-(N-Boc-amino)-3-methyl-4-hexenoic acid

: 223923-92-0
3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-propionylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / NaHCO₃ / dimethylformamide / 24 h / Ambient temperature

2: 90 percent / LiAlH₄ / diethyl ether / 1.5 h / Ambient temperature

3: 96 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

4: 90 percent / O₃, NaOH / 2.25 h / -78 °C

5: 84 percent / NBS / dimethylsulfoxide / 2 h / 10 °C

6: 123 mg / oxalyl chloride / CH₂Cl₂ / 1 h / -78 °C

7: 1.) n-BuLi / 1.) THF, -78 deg C (15 min), 0 deg C (30 min), 2.) THF, -> room temp., 20 h

8: 98 percent / aq. LiOH / tetrahydrofuran / 68 h / Ambient temperature

9: 88 percent / DCC, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

10: 81 percent Turnov_. / DMAP, diisopropylethylamine / acetonitrile / 90 h / Ambient temperature

With 1H-imidazole; dmap; lithium hydroxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; sodium hydrogencarbonate; ozone; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo982145i