1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole

Base Information

Chemical Name:1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole
CAS No.:885232-51-9
Molecular Formula:C₂₅H₂₄ClFN₄O
Molecular Weight:450.943
Hs Code.:

Synonyms:1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole

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Technology Process of 1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole

There total 1 articles about 1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 885232-50-8
4-[3-(4-chloro-benzyl)-6-fluoro-2-phenoxymethyl-3h-benzoimidazol-5-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 885232-51-9
1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole

Guidance literature:: 4-[3-(4-chloro-benzyl)-6-fluoro-2-phenoxymethyl-3h-benzoimidazol-5-yl]-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; pH=8;

Reference yield: 100.0%

: 885232-51-9
1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole

: 5239-82-7
cyclopropylacetic acid

: 1-{4-[3-(4-chloro-benzyl)-6-fluoro-2-phenoxymethyl-3H-benzoimidazol-5-yl]-piperazin-1-yl}-2-cyclopropyl-ethanone

Guidance literature:: cyclopropylacetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0166667h;

1-(4-chloro-benzyl)-5-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1H-benzoimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 22h;