9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Base Information

Chemical Name:9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride
CAS No.:1322646-07-0
Molecular Formula:C₃₁H₄₅N₃O₅S₂*ClH
Molecular Weight:640.308
Hs Code.:

Synonyms:9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

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Chemical Property of 9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

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Technology Process of 9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

There total 8 articles about 9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 620161-75-3
2-methylene-1,3-propane-[bis-(tert-butyl)carbonate]

: 1322645-10-2
N-(4-methoxybenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

: 1322646-07-0
9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Guidance literature:: 2-methylene-1,3-propane-[bis-(tert-butyl)carbonate]; N-(4-methoxybenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane; In acetonitrile; for 24h; Inert atmosphere; Reflux;

With hydrogenchloride; In methanol; water; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm2002603

Reference yield:

: C₁₇H₂₆N₂O₂S

: 1322646-07-0
9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Inert atmosphere

4.1: sodium carbonate; sodium chloride / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane / acetonitrile / 24 h / Inert atmosphere; Reflux

5.2: 4 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; 1,4-di(diphenylphosphino)-butane; sodium chloride; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603

Reference yield:

: 1322644-99-4
N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine

: 1322646-07-0
9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2.2: 1.5 h / Inert atmosphere

3.1: sodium carbonate; sodium chloride / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,4-di(diphenylphosphino)-butane / acetonitrile / 24 h / Inert atmosphere; Reflux

4.2: 4 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; 1,4-di(diphenylphosphino)-butane; sodium chloride; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603