1322644-99-4

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 56125-49-6 N-(3-aminopropyl)-p-toluenesulfonamide 
• 53364-99-1 N,N'-ditoluenesulfonyl-1,3-diaminopropane 

Downstream Products

• 1322645-03-3 N-(3-((3-aminopropyl)(cyclohexylmethyl)amino)propyl)-4-methylbenzenesulfonamide 
• 1322645-07-7 N-(4-t-butylbenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-08-8 N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-09-9 N-(5-isoquinolinesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-10-2 N-(4-methoxybenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-12-4 N-(naphthalene-1-sulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-15-7 N-(naphthalene-2-sulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-17-9 N-(4-nitrobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-22-6 N-(2-nitrobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine 
• 1322645-26-0 9-cyclohexylmethyl-1-(4-t-butylbenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane 
• 1322645-27-1 9-cyclohexylmethyl-1-(4-chlorobenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane 
• 1322645-29-3 9-cyclohexylmethyl-1-(5-isoquinolinesulfonyl)-3-methylene-5-(p-toluene-sulfonyl)-1,5,9-triazacyclododecane 
• 1322645-32-8 9-cyclohexylmethyl-1-(4-methoxybenzenesulfonyl)-3-methylene-5-(p-toluenesulfonyl)-1,5,9-triazacyclododecane 
• 1322645-34-0 9-cyclohexylmethyl-1-(naphthalene-1-sulfonyl)-3-methylene-5-(p-toluene-sulfonyl)-1,5,9-triazacyclododecane 

Relevant academic research and scientific papers

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies

Cyclotriazadisulfonamide prevents HIV entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signal peptide. According to a two-site binding model, 28 new unsymmetrical analogues bearing a benzyl tail group and nine

Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents

Cyclotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cell-surface and intracellular CD4. The specific biomolecular target of CADA compounds is unknown, but previous studies led to an unsymmetrical binding model. To test this model, methods were developed for effective synthesis of diverse, unsymmetrical CADA compounds. A total of 13 new, unsymmetrical target compounds were synthesized, as well as one symmetrical analogue. The new compounds display a wide range of potency for CD4 down-modulation in CHO-CD4-YFP cells. VGD020 (IC50 = 46 nM) is the most potent CADA compound discovered to date, and VGD029 (IC50 = 730 nM) is the most potent fluorescent analogue. Structure-activity relationships are analyzed from the standpoint of additive or nonadditive energy effects of different substituents. They appear to be consistent with the zipper-type mechanism in which entropy costs are reduced for additional stabilizing interactions between the small molecule and its protein target.