(E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide

Base Information

Chemical Name:(E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide
CAS No.:544417-30-3
Molecular Formula:C₃₁H₃₀ClN₅O₃
Molecular Weight:556.064
Hs Code.:

Synonyms:(E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide

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Chemical Property of (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide

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Technology Process of (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide

There total 7 articles about (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1055943-40-2
trans-4-dimethylamino crotonic acid chloride hydrochloride salt

: 544417-29-0
6-amino-4-(4-benzyloxy-3-chlorophenylamino)-7-ethoxyquinoline-3-carbonitrile

: 544417-30-3
(E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; acetonitrile; at 0 - 10 ℃; for 1.5h;

Reference yield:

: 544417-29-0
6-amino-4-(4-benzyloxy-3-chlorophenylamino)-7-ethoxyquinoline-3-carbonitrile

: 544417-30-3
(E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide

Guidance literature:: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In acetonitrile; at 63 ℃; for 0.333333h;

6-amino-4-(4-benzyloxy-3-chlorophenylamino)-7-ethoxyquinoline-3-carbonitrile; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 0 ℃; for 2h;