1055943-40-2

Basic information

• Product Name: (E)-4-(diMethylaMino)but-2-enoyl chloride
• Synonyms: (E)-4-(diMethylaMino)but-2-enoyl chloride;4-(DIMETHYLAMINO)BUT-2-ENOYL CHLORIDE
• CAS NO: 1055943-40-2
• Molecular Formula: C₆H₁₀ClNO*ClH
• Molecular Weight: 147.6027
• EINECS: -0
• Mol File: 1055943-40-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-4-(diMethylaMino)but-2-enoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(diMethylaMino)but-2-enoyl chloride(1055943-40-2)
• EPA Substance Registry System: (E)-4-(diMethylaMino)but-2-enoyl chloride(1055943-40-2)

Safety Data

• Hazardous Substances Data: 1055943-40-2(Hazardous Substances Data)

Usage

General Description

(E)-4-(dimethylamino)but-2-enoyl chloride is a chemical compound with the molecular formula C8H14ClNO. It is a yellowish liquid that is used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. (E)-4-(diMethylaMino)but-2-enoyl chloride has a reactive acyl chloride functional group, which makes it useful in organic reactions such as acylation and amidation. It is also known for its role as a key reagent in the synthesis of various heterocyclic compounds. Additionally, (E)-4-(dimethylamino)but-2-enoyl chloride is used in the development of new materials and as a building block in organic chemistry research. Due to its versatile nature, this compound is commonly used in the pharmaceutical and chemical industries for various applications.

Upstream product

• 79-37-8 oxalyl dichloride 
• 1130155-48-4 (E)-4-(dimethylamino)-2-butenoic acid hydrochloride 
• 98548-81-3 trans-4-dimethylaminocrotonic acid hydrochloride 
• 1421354-12-2 (E)-4-dimethylamino-but-2-enoic acid tert-butyl ester 

Downstream Products

• 544417-30-3 (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide 
• 698387-09-6 neratinib 
• 850140-72-6 afatinib 

Relevant articles and documents

Preparation method of neratinib

The invention relates to a preparation method of neratinib. The preparation method specifically comprises the steps: (1) in an organic solvent 1, trans-4-dimethylaminocrotonic acid hydrochloride and achloride agent react, and thus a solution containing (e)-4-(dimethylamino)but-2-enoyl chloride (hydrochloride) is obtained; (2) a solution of an organic solvent 2 containing 6-amino-4-[[3-chloro-4-[(pyridine-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinoline is added into the solution obtained in the step (1) to react, and then neratinib hydrochloride is obtained; and (3) the neratinib hydrochloride obtained in the step (2) is mixed with water and an organic solvent 3, a reaction is carried out after the pH value is regulated to be 7-10, and then the neratinib is obtained. The synthesis method has the advantages that the yield is high, the product purity is high, the production cost is low, operation is safe, easy and convenient, and large-scale industrial production is easy.

QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a quinazoline derivative, a preparation method therefor, and a pharmaceutical composition and an application thereof. The present invention provides a compound represented by general formula I, a stereoisomer thereof and a pharmaceutical acceptable salt or a solvate thereof. The quinazoline derivative of the present invention has a unique chemical structure, is characterized by irreversibly inhibiting EGFR tyrosine kinase, has high biological activity, apparently improves the inhibiting effect on the EGFR tyrosine kinase, has quite strong tumor inhibiting effect on tumor cells and a transplantation tumor pathological model of animal tumors, and has good market developing prospects.

Method for purifying neratinib

The invention relates to a method for purifying neratinib. The method provided by the invention is capable of effectively reducing the content of impurities in neratinib and preparing high-purity neratinib, and moreover is simple in operation, high in yield and very applicable to industrial production.