(S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate

Base Information

• Chemical Name: (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate
• CAS No.: 1360538-90-4
• Molecular Formula: C₂₀H₃₂N₂O₇S
• Molecular Weight: 444.549
• Mol file: 1360538-90-4.mol

Synonyms:(S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate

Chemical Property of (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate

There total 4 articles about (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptan-1-ol (913625-37-3) + methanesulfonyl chloride (124-63-0) → (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate (1360538-90-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate (1360538-90-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 16 h / 20 °C

2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3.1: tetrahydrofuran / 16 h / 80 °C

3.2: 3 h / 20 - 35 °C

4.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;

Reference yield:

(S)-(-)-N-(benzyloxycarbonyl)alaninol (6429-44-3,61425-27-2,87905-97-3,66674-16-6) → (S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptyl methanesulfonate (1360538-90-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: tetrahydrofuran / 16 h / 80 °C

2.2: 3 h / 20 - 35 °C

3.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(S)-6-benzyloxycarbonylamino-4-(tert-butoxycarbonyl)-4-azaheptan-1-ol

methanesulfonyl chloride

benzyl chloroformate

(S)-(-)-N-(benzyloxycarbonyl)alaninol

Downstream raw materials:

ripasudil

tert-butyl (S)-3-methyl-1,4-diazepane-1-carboxylate

(S)-1-benzyl 4-tert-butyl 2-methyl-1,4-diazepane-1,4-dicarboxylate