6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

Base Information

Chemical Name:6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile
CAS No.:1388817-18-2
Molecular Formula:C₂₀H₂₁Cl₃N₄OSi
Molecular Weight:467.857
Hs Code.:

Synonyms:6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

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Chemical Property of 6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

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Technology Process of 6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

There total 9 articles about 6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388817-17-1
4,6-dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

: 117269-75-7
(2,6-dichlorobenzyl)zinc(II) bromide

: 1388817-18-2
6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 65 ℃; for 14h; Inert atmosphere;

Reference yield:

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1388817-18-2
6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 2.58 h / -10 - 100 °C

1.2: 40 °C / pH 8

2.1: N-Bromosuccinimide; acetic acid / 2 h / 60 °C

2.2: 0.5 h / 80 °C

3.1: hydrogen / Raney nickel / ethanol / 12 h / 20 °C

4.1: acetic anhydride / 4 h / 120 °C / Inert atmosphere

5.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.17 h / -60 °C / Inert atmosphere

5.2: 2 h

6.1: thionyl chloride / 2 h / 75 °C

6.2: 10 h / 0 - 20 °C

7.1: trichlorophosphate / 3 h / 90 °C

8.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 14 h / 65 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; hydrogen; nitric acid; acetic anhydride; acetic acid; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol;

Reference yield:

: 1388817-11-5
3-bromo-2,6-dichloro-5-nitropyridin-4-amine

: 1388817-18-2
6-chloro-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridine-7-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / Raney nickel / ethanol / 12 h / 20 °C

2.1: acetic anhydride / 4 h / 120 °C / Inert atmosphere

3.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.17 h / -60 °C / Inert atmosphere

3.2: 2 h

4.1: thionyl chloride / 2 h / 75 °C

4.2: 10 h / 0 - 20 °C

5.1: trichlorophosphate / 3 h / 90 °C

6.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 14 h / 65 °C / Inert atmosphere

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; hydrogen; acetic anhydride; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol;