4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

Base Information

Chemical Name:4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate
CAS No.:1388817-10-4
Molecular Formula:CH₂O₂*C₂₅H₂₅Cl₂N₇O₂
Molecular Weight:572.451
Hs Code.:

Synonyms:4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

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Chemical Property of 4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

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Technology Process of 4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

There total 11 articles about 4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 1388817-19-3
tert-butyl 4-(4-(7-cyano-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate

: 1388817-10-4
4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

Guidance literature:: tert-butyl 4-(4-(7-cyano-4-(2,6-dichlorobenzyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate; With sulfuric acid; water; at 0 - 95 ℃; for 0.5h;

With sodium hydrogencarbonate; pH=8 - 9;

formic acid; In water; acetonitrile;

Reference yield:

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1388817-10-4
4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

Guidance literature:: Multi-step reaction with 11 steps

1.1: nitric acid; sulfuric acid / 2.58 h / -10 - 100 °C

1.2: 40 °C / pH 8

2.1: N-Bromosuccinimide; acetic acid / 2 h / 60 °C

2.2: 0.5 h / 80 °C

3.1: hydrogen / Raney nickel / ethanol / 12 h / 20 °C

4.1: acetic anhydride / 4 h / 120 °C / Inert atmosphere

5.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.17 h / -60 °C / Inert atmosphere

5.2: 2 h

6.1: thionyl chloride / 2 h / 75 °C

6.2: 10 h / 0 - 20 °C

7.1: trichlorophosphate / 3 h / 90 °C

8.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

9.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 14 h / 65 °C / Inert atmosphere

10.1: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene / 12 h / 95 °C / Inert atmosphere

11.1: water; sulfuric acid / 0.5 h / 0 - 95 °C

11.2: pH 8 - 9

With N-Bromosuccinimide; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; water; hydrogen; nitric acid; acetic anhydride; caesium carbonate; acetic acid; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1388817-11-5
3-bromo-2,6-dichloro-5-nitropyridin-4-amine

: 1388817-10-4
4-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1H-imidazo[4,5-c]pyridine-7-carboxamide monoformate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / Raney nickel / ethanol / 12 h / 20 °C

2.1: acetic anhydride / 4 h / 120 °C / Inert atmosphere

3.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.17 h / -60 °C / Inert atmosphere

3.2: 2 h

4.1: thionyl chloride / 2 h / 75 °C

4.2: 10 h / 0 - 20 °C

5.1: trichlorophosphate / 3 h / 90 °C

6.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 14 h / 65 °C / Inert atmosphere

8.1: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene / 12 h / 95 °C / Inert atmosphere

9.1: water; sulfuric acid / 0.5 h / 0 - 95 °C

9.2: pH 8 - 9

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; water; hydrogen; acetic anhydride; caesium carbonate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; ethanol; toluene;