{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

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Chemical Name:{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid
CAS No.:660425-74-1
Molecular Formula:C₂₇H₄₀N₄O₆
Molecular Weight:516.638
Hs Code.:

Synonyms:{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

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Chemical Property of {(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

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Technology Process of {(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

There total 5 articles about {(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 660425-73-0
{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid methyl ester

: 660425-74-1
{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; water;
DOI:10.1016/j.bmc.2003.08.030

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 660425-74-1
{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: NMM; isobutyl chloroformate / tetrahydrofuran / 0.08 h / 0 °C

1.2: 70 percent / tetrahydrofuran / 1 h

2.1: 100 percent / HCl / dioxane / 3 h

3.1: 12.7 g / glacial AcOH; NaBH(OAc)3 / 4 h

4.1: 100 percent / H₂O / 0.5 h / Heating

5.1: 94 percent / KOH / dioxane; H₂O

With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/j.bmc.2003.08.030

Reference yield:

: 27560-15-2,119621-63-5,120089-68-1
methyl 2-(2-amino-4-methylpentanamido)acetate

: 660425-74-1
{(S)-3-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-5-oxo-imidazolidin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 12.7 g / glacial AcOH; NaBH(OAc)3 / 4 h

2: 100 percent / H₂O / 0.5 h / Heating

3: 94 percent / KOH / dioxane; H₂O

With potassium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane; water;
DOI:10.1016/j.bmc.2003.08.030