BMS813160

Base Information

Chemical Name:BMS813160
CAS No.:1286279-29-5
Molecular Formula:C₂₅H₄₀N₈O₂
Molecular Weight:484.645
Hs Code.:
Mol file:1286279-29-5.mol

Synonyms:N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide

Suppliers and Price of BMS813160

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BMS-813160
1mg
$ 305.00

DC Chemicals
BMS813160 >98%
100 mg
$ 650.00

ChemScene
BMS-813160 99.89%
100mg
$ 1950.00

ChemScene
BMS-813160 99.89%
50mg
$ 1350.00

ChemScene
BMS-813160 99.89%
2mg
$ 140.00

ChemScene
BMS-813160 99.89%
10mg
$ 450.00

ChemScene
BMS-813160 99.89%
5mg
$ 280.00

Cayman Chemical
BMS 813160
1mg
$ 199.00

Cayman Chemical
BMS 813160
5mg
$ 796.00

AK Scientific
N-[(1R,2S,5R)-5-(Tert-butylamino)-2-[(3S)-3-[(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-yl)amino]-2-oxopyrrolidin-1-yl]cyclohexyl]acetamide
5mg
$ 1174.00

Total 9 raw suppliers

Chemical Property of BMS813160

Chemical Property:

PKA:15.46±0.60(Predicted)
Density:1.31±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

BMS-813160 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.
Uses BMS-813160, a dual CCR2/CCR5 chemokine antagonist.

Technology Process of BMS813160

There total 16 articles about BMS813160 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (S)-1-((1S,2R,4R)-2-acetamido-4-(tert-butylammonio)cyclohexyl)-2-oxopyrrolidin-3-aminium bromide

: C₁₃H₁₇N₆⁽¹⁺⁾

: 1286279-29-5
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide

Guidance literature:: In dichloromethane; at 0 ℃;

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1286279-29-5
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate; benzene / 16 h / 5 - 20 °C

2: sodium hydroxide / water / 2 h / 20 °C

3: ammonium hydroxide / water; methanol / 4 h / 100 °C

4: trichlorophosphate / Reflux

5: triethylamine / isopropyl alcohol / 3 h

With ammonium hydroxide; triethylamine; sodium hydroxide; trichlorophosphate; In methanol; water; ethyl acetate; isopropyl alcohol; benzene;
DOI:10.1021/acsmedchemlett.1c00373