1004536-75-7Relevant academic research and scientific papers
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2
Yang, Michael G.,Xiao, Zili,Zhao, Rulin,Tebben, Andrew J.,Wang, Bei,Cherney, Robert J.,Batt, Douglas G.,Brown, Gregory D.,Cvijic, Mary Ellen,Duncia, John V.,Gallela, Michael A.,Gardner, Daniel S.,Khandelwal, Purnima,Malley, Mary F.,Pang, Jian,Rose, Anne V.,Santella, Joseph B.,Sarjeant, Amy A.,Xu, Songmei,Mathur, Arvind,Mandlekar, Sandhya,Vuppugalla, Ragini,Zhao, Qihong,Carter, Percy H.
, p. 969 - 975 (2021/06/25)
To improve the metabolic stability profile of BMS-741672 (1a), we undertook a structure-activity relationship study in our trisubstituted cyclohexylamine series. This ultimately led to the identification of 2d (BMS-753426) as a potent and orally bioavaila
CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 21, (2008/06/13)
This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and
