N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

Base Information

Chemical Name:N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide
CAS No.:894853-78-2
Molecular Formula:C₂₃H₂₆ClF₂NO₅S₂
Molecular Weight:534.045
Hs Code.:

<i>N</i>-allyl-<i>N</i>-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

Synonyms:N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

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Technology Process of N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

There total 8 articles about N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 894853-77-1
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexyl]-methanesulfonamide

: 894853-78-2
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1016/j.bmcl.2005.12.083

Reference yield:

: 471903-20-5
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone

: 894853-78-2
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nBuLi; LiCl; [S-(R*,R*)]-(-)-bis-α-methylbenzylamine / tetrahydrofuran / -100 °C

1.2: 75 percent / SnCl₄ / CH₂Cl₂ / -40 °C

2.1: 80 percent / NaBH₄ / propan-2-ol / -20 °C

3.1: 97 percent / Et₃N / CH₂Cl₂

4.1: 75 percent / NaN₃ / dimethylformamide / 90 °C

5.1: 95 percent / Ph₃P; water / tetrahydrofuran

6.1: 95 percent / Et₃N / CH₂Cl₂

7.1: 70 percent / NaH / dimethylformamide / 70 °C

8.1: 95 percent / BF₃*Et₂O / CH₂Cl₂

With sodium tetrahydroborate; n-butyllithium; sodium azide; [S-(R*,R*)]-(-)-bis-α-methylbenzylamine; boron trifluoride diethyl etherate; water; sodium hydride; triethylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.12.083

Reference yield:

: 894853-74-8
(2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone

: 894853-78-2
N-allyl-N-[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / NaBH₄ / propan-2-ol / -20 °C

2: 97 percent / Et₃N / CH₂Cl₂

3: 75 percent / NaN₃ / dimethylformamide / 90 °C

4: 95 percent / Ph₃P; water / tetrahydrofuran

5: 95 percent / Et₃N / CH₂Cl₂

6: 70 percent / NaH / dimethylformamide / 70 °C

7: 95 percent / BF₃*Et₂O / CH₂Cl₂

With sodium tetrahydroborate; sodium azide; boron trifluoride diethyl etherate; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2005.12.083