(2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone

Base Information

• Chemical Name: (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone
• CAS No.: 894853-74-8
• Molecular Formula: C₂₄H₂₉ClF₂O₄SSi
• Molecular Weight: 515.093

Synonyms:(2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone

Chemical Property of (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone

There total 2 articles about (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone (471903-20-5) + chloro-trimethyl-silane (75-77-4) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone (894853-74-8)

Guidance literature:

4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone; chloro-trimethyl-silane; With n-butyllithium; [S-(R*,R*)]-(-)-bis-α-methylbenzylamine; lithium chloride; In tetrahydrofuran; at -100 ℃;

(2-trimethylethylsilylethoxy)methyl chloride; With tin(IV) chloride; In dichloromethane; at -40 ℃;

DOI:10.1016/j.bmcl.2005.12.083

Reference yield:

→ (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone (894853-74-8)

Guidance literature:

Reference yield: 80.0%

(2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone (894853-74-8) → (1S,2R,4S)-4-(4-Chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexanol

Guidance literature:

With sodium tetrahydroborate; In isopropyl alcohol; at -20 ℃;

DOI:10.1016/j.bmcl.2005.12.083

upstream raw materials:

4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone

chloro-trimethyl-silane

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

(2-{(1S,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-[1-methanesulfonyl-meth-(E)-ylidene]-cyclohexylmethoxy}-ethyl)-trimethyl-silane

(4aS,6S,8aR)-6-(4-Chloro-benzenesulfonyl)-6-(2,5-difluoro-phenyl)-3-eth-(E)-ylidene-octahydro-isothiochromene 2,2-dioxide

(4aS,6S,8aR)-1-Allyl-6-(4-chloro-benzenesulfonyl)-6-(2,5-difluoro-phenyl)-octahydro-benzo[c][1,2]thiazine 2,2-dioxide

(1R,2S,4S)-4-(4-Chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexylamine

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