ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate

Base Information

• Chemical Name: ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate
• CAS No.: 1365762-43-1
• Molecular Formula: C₂₁H₂₄N₂O₃
• Molecular Weight: 352.433
• Mol file: 1365762-43-1.mol

Synonyms:ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate

Chemical Property of ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate

There total 6 articles about ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

chloroformic acid ethyl ester (541-41-3) + 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethan-1-amine (157561-19-8) → ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate (1365762-43-1)

Guidance literature:

With sodium carbonate; In chloroform;

Reference yield:

1-[(4-methoxyphenyl)methyl]-1H-indole-3-carboxaldehyde (928835-08-9) → ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate (1365762-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

3: sodium carbonate / chloroform

With lithium aluminium tetrahydride; ammonium acetate; sodium carbonate; In tetrahydrofuran; chloroform;

Reference yield:

(Z)-1-(4-methoxybenzyl)-3-(2-nitrovinyl)-1H-indole → ethyl 2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethylcarbamate (1365762-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

2: sodium carbonate / chloroform

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; chloroform;

upstream raw materials:

chloroformic acid ethyl ester

2-(1-(4-methoxybenzyl)-1H-indol-3-yl)ethan-1-amine

1-[(4-methoxyphenyl)methyl]-1H-indole-3-carboxaldehyde

indole

Downstream raw materials:

1,2,3,4-tetrahydronorharman-1-one