t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

Base Information

Chemical Name:t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate
CAS No.:1287285-87-3
Molecular Formula:C₂₁H₃₅NO₄
Molecular Weight:365.513
Hs Code.:

Synonyms:t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

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Chemical Property of t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

Chemical Property:

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Technology Process of t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

There total 4 articles about t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1287285-61-3
methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-{4-[(2-methylpentyl)oxy]phenyl}acetate

: 75-16-1
methylmagnesium bromide

: 1287285-87-3
t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

Guidance literature:: methyl (2R)-2-(tert-butoxycarbonylamino)-2-[4-(2-methylpentyloxy)phenyl]acetate; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 1287285-87-3
t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h

1.2: 18 h / 20 °C

2.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

With triphenylphosphine; In tetrahydrofuran; diethyl ether;

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 1287285-87-3
t-butyl (1R)-2-hydroxy-2-methyl-1-(4-(2-methylpentyloxy)phenyl)-propylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h

2.2: 18 h / 20 °C

3.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane;