12alpha-Hydroxyprogesterone

Base Information

Chemical Name:12alpha-Hydroxyprogesterone
CAS No.:19897-02-0
Molecular Formula:C₂₁H₃₀O₃
Molecular Weight:330.467
Hs Code.:
NSC Number:60778
UNII:8632QLR8C5
DSSTox Substance ID:DTXSID90941771
Nikkaji Number:J337.174C
Wikidata:Q27115852
Metabolomics Workbench ID:35427
Mol file:19897-02-0.mol

Synonyms:12 alpha-hydroxyprogesterone

Suppliers and Price of 12alpha-Hydroxyprogesterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 12alpha-Hydroxyprogesterone

Chemical Property:

Vapor Pressure:1.51E-11mmHg at 25°C
Boiling Point:487.4°Cat760mmHg
Flash Point:262.7°C
PSA：54.37000
Density:1.15g/cm³
LogP:3.69430
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:330.21949481
Heavy Atom Count:24
Complexity:621

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1CCC2C1(C(CC3C2CCC4=CC(=O)CCC34C)O)C
Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C

Technology Process of 12alpha-Hydroxyprogesterone

There total 5 articles about 12alpha-Hydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83603-62-7
12α-acetoxy-pregn-4-ene-3,20-dione

: 19897-02-0
12α-Hydroxyprogesterone

Guidance literature:: With potassium carbonate;
DOI:10.1021/jo01095a004

Reference yield:

: 19897-02-0
12α-Hydroxyprogesterone

Guidance literature:: With pyridine; Erwaermen des erhaltenen 12α-Acetoxy-pregnen-(4)-dions-(3.20) mit methanol. KOH;
DOI:10.1002/hlca.19430260303

Reference yield:

: 114276-27-6
4β-bromo-12α-acetoxy-5Hβ-pregnan-3,20-dione

: 19897-02-0
12α-Hydroxyprogesterone

Guidance literature:: Multi-step reaction with 2 steps

1: semicarbazide; pyruvic acid

2: aqueous methanol.K₂CO₃

With potassium carbonate; 2-oxo-propionic acid; hydrazine carboxamide;
DOI:10.1021/jo01095a004