2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)

Base Information

Chemical Name:2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)
CAS No.:358369-11-6
Molecular Formula:C₂₂H₃₂O₇
Molecular Weight:408.492
Hs Code.:

Synonyms:2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)

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Chemical Property of 2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)

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Technology Process of 2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)

There total 2 articles about 2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 541-16-2
t-butyl malonate

: 36287-36-2
2-chloro-1-(3,4-dimethoxyphenyl)propan-1-one

: 358369-11-6
2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)

Guidance literature:: t-butyl malonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

2-chloro-1-(3,4-dimethoxyphenyl)propan-1-one; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 5h; Further stages.;
DOI:10.1021/jm010837k

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 358369-11-6
2-[2-(3,4-dimethoxyphenyl)-1-methyl-2-oxoethyl]malonic acid di(tert-butyl ester)

Guidance literature:: Multi-step reaction with 2 steps

1.1: 61 percent / AlCl₃ / 1,2-dichloro-ethane / 28 h / Heating

2.1: NaH / dimethylformamide / 20 °C

2.2: dimethylformamide / 5 h / 20 - 50 °C

With aluminium trichloride; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Friedel-Crafts acylation;
DOI:10.1021/jm010837k