N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

Base Information

Chemical Name:N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine
CAS No.:340721-56-4
Molecular Formula:C₃₀H₄₇N₅O₅Si₂
Molecular Weight:613.905
Hs Code.:

N<sup>6</sup>-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

Synonyms:N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

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Chemical Property of N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

Chemical Property:

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Technology Process of N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

There total 4 articles about N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[8-formyl-9-(4-triethylsilanyloxy-5-triethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

: 340721-56-4
N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

Guidance literature:: N-[8-formyl-9-(4-triethylsilanyloxy-5-triethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide; With acetic acid; In tetrahydrofuran; at 23 ℃;

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; acetic acid; at 23 ℃; for 0.416667h;
DOI:10.1002/1522-2675(20010321)84:3<594::AID-HLCA594>3.0.CO;2-9

Reference yield:

: 994-30-9
triethylsilyl chloride

: 340721-56-4
N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / imidazole / dimethylformamide / 16 h / 23 °C

2.1: LDA / tetrahydrofuran; hexane / 2.5 h / -70 °C

3.1: AcOH / tetrahydrofuran / 23 °C

3.2: NaBH₄ / ethanol; tetrahydrofuran; acetic acid / 0.42 h / 23 °C

With 1H-imidazole; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(20010321)84:3<594::AID-HLCA594>3.0.CO;2-9

Reference yield:

: 4546-72-9
N₆-benzoyl-2'-deoxyadenosine

: 340721-56-4
N⁶-benzoyl-2'-deoxy-8-(hydroxymethyl)-3',5'-bis-O-(triethylsilyl)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / imidazole / dimethylformamide / 16 h / 23 °C

2.1: LDA / tetrahydrofuran; hexane / 2.5 h / -70 °C

3.1: AcOH / tetrahydrofuran / 23 °C

3.2: NaBH₄ / ethanol; tetrahydrofuran; acetic acid / 0.42 h / 23 °C

With 1H-imidazole; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(20010321)84:3<594::AID-HLCA594>3.0.CO;2-9