2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside

Base Information

• Chemical Name: 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside
• CAS No.: 1442745-11-0
• Molecular Formula: C₄₁H₅₈O₂₄S
• Molecular Weight: 966.963
• Mol file: 1442745-11-0.mol

Synonyms:2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside

Chemical Property of 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside

There total 4 articles about 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester (77544-60-6) + 1',2',3',6',2,3,4,6-octa-O-acetyl-β-D-lactose (3616-19-1,5328-50-7,5346-90-7,6291-42-5,6920-00-9,20764-63-0,20880-60-8,20880-65-3,22352-19-8,23973-20-8,32447-69-1,34213-32-6,52554-32-2,53956-64-2,56907-29-0,56994-12-8,56994-13-9,57128-38-8,67650-36-6,68036-17-9,68036-19-1,78215-50-6,78215-51-7,79549-48-7,80446-82-8,85249-04-3,93221-83-1,93779-27-2,111407-83-1,111407-84-2,111407-85-3,120328-65-6,123809-59-6,132341-46-9,132341-47-0,132341-49-2,145307-94-4) → 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside (1442745-11-0)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja403323y

Reference yield:

toluene-4-sulfonic acid (104-15-4) → 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside (1442745-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 h / 25 °C

2: boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

With pyridine; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1021/ja403323y

Reference yield:

LACTOSE (5965-66-2) → 2-(2-{2-[2-(2-tosyloxyethoxy)ethoxy]ethoxy}ethyl) 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6 tri-O-acetyl-β-D-glucopyranoside (1442745-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / Reflux

2: boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

With boron trifluoride diethyl etherate; sodium acetate; In dichloromethane;

DOI:10.1021/ja403323y

upstream raw materials:

toluene-4-sulfonic acid

LACTOSE

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

1',2',3',6',2,3,4,6-octa-O-acetyl-β-D-lactose