77544-60-6

Basic information

• Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
• Synonyms: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol;Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-Methylbenzenesulfonate);2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylate;Monotosylated tetraethylene glycol;Tetraethylene glycol monotosylate
• CAS NO: 77544-60-6
• Molecular Formula: C₁₅H₂₄O₇S
• Molecular Weight: 348.41
• Mol File: 77544-60-6.mol
• Article Data: 120

Chemical Properties

• Boiling Point: 492.5±40.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.202 g/mL at 25 °C
• Refractive Index: n20/D1.507
• Storage Temp.: 2-8°C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(77544-60-6)
• EPA Substance Registry System: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(77544-60-6)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2927 8(6.1) / PGII
• WGK Germany: 3
• Hazardous Substances Data: 77544-60-6(Hazardous Substances Data)

Usage

Description

PEG5-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 2615-15-8 pentaethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 
• 96922-86-0 1,21-diphenyl-2,5,8,11,14,17,20-heptaoxahenicosane 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 128134-70-3 1-hydroxy-11-(4'-nitrophenoxy)-3,6,9-trioxaundecane 
• 134881-76-8 1,4-bis<2-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>ethoxy>benzene 
• 188915-75-5 11-acryloxy-3,6,9-trioxa-undecyl tosylate 
• 224298-57-1 4,4'-bis<2-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>ethoxy>azobenzene 
• 333382-87-9 2-(2-(2-(2-(4-bromophenoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol 
• 223611-42-5 S-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl)thioacetate 
• 1104643-17-5 3,6-bis(2-(2-[2-(2-hydroxyethoxy)ethoxy]ethoxy)ethoxy)phthalonitrile 
• 1190438-57-3 C₂₂H₃₆Br₂O₁₀ 
• 945529-16-8 BHEEEEN monotosylate 
• 1280220-36-1 C₅₆H₇₈N₆O₁₀ 
• 1268273-72-8 N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide 
• 1391838-80-4 N-(11-(p-tolylsulfonyloxy)-3,6,9-trioxaundecan-1-yl)-exo-norborn-5-en-2,3-dicarboximide 
• 1373391-26-4 C₃₄H₄₆O₁₆S₂ 
• 1401703-32-9 C₃₇H₄₇N₃O₁₂ 

Relevant articles and documents

Lysine-Based C60-Fullerene Nanoconjugates for Monomethyl Fumarate Delivery: A Novel Nanomedicine for Brain Cancer Cells

In the present study, water-soluble lysine-based C60-fullerene nanoconjugates (CF-LYS-TEG-MMF) were synthesized using a biodegradable linker for the better delivery of monomethyl fumarate (MMF) employing Prato reaction. CF-LYS-TEG-MMF resulted

Honeycomb membranes prepared from 3-O-amino acid functionalized cellulose derivatives

The development of value-added wood-derived polymer products is of significant importance. Of particular interest is the synthesis of advanced bioactive cellulosic materials. In the present research, novel cellulosic honeycomb films are reported. Cellulos

Vesicle aggregation by multivalent ligands: Relating crosslinking ability to surface affinity

In an effort to improve the stability of our tissue-mimetic vesicle aggregates, we have investigated how increasing the valency of our multivalent crosslinking ligand, poly-l-histidine, affected both the extent of vesicle aggregation and the affinity of t

BisPNA targeting to DNA: Effect of neutral loop on DNA duplex strand invasion by aepPNA-N7G/aepPNA-C substituted peptide nucleic acids

N7-Alkyl-substituted guanine (N7G) as a CH+ mimic has been introduced into aminoethylglycyl PNA (aegPNA) forming a hairpin through a neutral linker derived from bis(tetraethylene) glycol (teg-teg). These form pH-independent PNA2:DNA

Precise macroscopic supramolecular assembly of photopatterned hydrogels

Here we demonstrate that a precise macroscopic supramolecular assembly (MSA) can be achieved using a surface photopatterning strategy. The electrostatic interaction of the photopatterned polyelectrolytes drives hydrogel cuboids to form a stable MSA on a m

An air-tolerant polymer gel-immobilized iridium photocatalyst with pumping recyclability properties

A novel methacrylate-based cross-linked polymer gel bearing an iridium photocatalyst showed air tolerance and pumping recyclability features through its tunable swelling and deswelling ability. The photocatalytic activity of the polymer gel was demonstrated through an E-to-Z isomerisation reaction and in an azide-alkene [2+3] cycloaddition.

Solvent-Driven Supramolecular Wrapping of Self-Assembled Structures

Self-assembly relies on the ability of smaller and discrete entities to spontaneously arrange into more organized systems by means of the structure-encoded information. Herein, we show that the design of the media can play a role even more important than