5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

Base Information

Chemical Name:5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile
CAS No.:1092486-03-7
Molecular Formula:C₁₇H₇Cl₃F₄N₂O
Molecular Weight:437.608
Hs Code.:

Synonyms:5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

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Chemical Property of 5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

Chemical Property:

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Technology Process of 5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

There total 4 articles about 5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864736-87-8
1,2,3-trichloro-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: 218301-30-5
2-fluoro-5-[(hydroxyimino)methyl]benzonitrile

: 1092486-03-7
5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

Guidance literature:: With sodium hypochlorite; In tetrahydrofuran; at 0 - 25 ℃;
DOI:10.1016/j.bmcl.2013.03.031

Reference yield:

: 942069-95-6
3,4,5-trichlorophenylboronic acid pinacol ester

: 1092486-03-7
5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide / water; 1,2-dimethoxyethane; tetrahydrofuran / 75 °C

2: sodium hypochlorite / tetrahydrofuran / 0 - 25 °C

With sodium hypochlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.03.031

Reference yield:

: 87-61-6
1,2,3-trichlorobenzene

: 1092486-03-7
5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 2-(((2,6-diisopropylphenyl)imino)methyl)pyridine / bis(1,5-cyclooctadiene)diiridium(I) dichloride / n-heptane / 18 h / Heating / reflux

2: potassium hydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; 1,2-dimethoxyethane; water / 6 h / 75 °C

3: tetrahydrofuran / 3 h / 20 °C

With potassium hydroxide; 2-(((2,6-diisopropylphenyl)imino)methyl)pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(1,5-cyclooctadiene)diiridium(I) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; n-heptane; water;