218301-30-5

Upstream product

• 218301-22-5 2-fluoro-5-formylbenzonitrile 

Downstream Products

• 1092485-96-5 5-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile 
• 1092486-08-2 5-[4,5-dihydro-5-(trifluoromethyl)-5-[3-(trifluoromethyl)phenyl]-3-isoxazolyl]-2-fluorobenzonitrile 
• 1092486-03-7 5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-fluorobenzonitrile 
• 1196871-70-1 C₈H₄ClFN₂O 
• 1318072-98-8 ethyl 3-(3-cyano-4-fluorophenyl)-5-methylisoxazole-4-carboxylate 
• 1092486-49-1 C₂₀H₁₂Cl₂F₃N₅O 
• 1007317-81-8 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-fluorobenzonitrile 
• 943137-95-9 5-[5-(3,5-dibromophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile 
• 1092486-46-8 C₂₀H₉Cl₂F₃N₆O 
• 1432445-01-6 C₂₀H₁₂Cl₂F₃N₅O₂ 
• 1092486-68-4 C₂₀H₉Cl₂F₃N₆O 
• 1092485-68-1 5-[5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile 
• 1045407-67-7 5-[4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile 

Relevant academic research and scientific papers

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

An efficient one-pot synthesis of 3-aryl-5-methylisoxazoles from aryl aldehydes

An efficient protocol for the one-pot preparation of alkyl 3-aryl-5-methylisoxazole-4-carboxylates from aryl aldehydes is described. This method is readily amenable to the large scale preparation of isoxazoles as well as the parallel synthesis of isoxazole libraries.

PYRAZOLE-SUBSTITUTED ISOXAZOLINE INSECTICIDES

Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, wherein R1 is F, Cl, Br, CF3, OCHF2, OCF3 or OCH2CF3; R2 is H, F, Cl, Br, CHsub

3-CYANO-4-TRIAZOLYL PHENYLISOXAZOLINE INVERTEBRATE PEST CONTROL AGENTS

Disclosed are compounds of Formula 1, N-oxides, and salts thereof; Formula (I) wherein R1 is F, Cl, Br, cyano, CF3, OCF2H, OCF3 or OCH2CF3; R2 is H, F, Cl, Br, CH3, cy

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors

Factor Xa (fXa) is an important serine protease in the blood coagulation cascade. Inhibition of fXa has emerged as an attractive target for potential therapeutic applications in the treatments of both arterial and venous thrombosis. Herein, we describe a series of non-benzamidine isoxazoline derivatives as fXa inhibitors. The chloroaniline group was found to be the most potent benzamidine mimic in this series. Chloroaniline 1 (ST368) has a Ki value of 1.5 nM against fXa and is highly selective for fXa relative to thrombin and trypsin.

Guanidine mimics as factor Xa inhibitors

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings D—E represent guanidine mimics, which are useful as inhibitors of factor Xa.