alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile

Base Information

Chemical Name:alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile
CAS No.:109929-61-5
Molecular Formula:C₂₀H₁₇N₃O
Molecular Weight:315.374
Hs Code.:
DSSTox Substance ID:DTXSID001188265

Synonyms:DTXSID001188265;alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile;109929-61-5

Suppliers and Price of alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:315.137162174
Heavy Atom Count:24
Complexity:431

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CC(C#N)(C2=CC=CC=C2)C3=NC=CN=C3

Technology Process of alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile

There total 2 articles about alpha-[(4-Methoxyphenyl)methyl]-alpha-phenyl-2-pyrazineacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2746-25-0
p-Methoxybenzyl bromide

: 1080-87-1
α-(2-pyrazinyl)phenylacetonitrile

: 109929-61-5
3-(4-Methoxy-phenyl)-2-phenyl-2-pyrazin-2-yl-propionitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/je00050a031

Reference yield:

: 140-29-4
phenylacetonitrile

: 109929-61-5
3-(4-Methoxy-phenyl)-2-phenyl-2-pyrazin-2-yl-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / dimethylsulfoxide

2: 70 percent / NaH / dimethylformamide

With sodium hydroxide; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/je00050a031