1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

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Chemical Name:1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol
CAS No.:1384424-13-8
Molecular Formula:C₄₉H₇₇F₂N₃O₁₁
Molecular Weight:922.161
Hs Code.:

Synonyms:1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

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Chemical Property of 1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

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Technology Process of 1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

There total 11 articles about 1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 104-03-0
4-nitrobenzeneacetic acid

: 1384424-12-7
1-O-(6-amino-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

: 1384424-13-8
1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Guidance literature:: With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1384424-10-5
1-O-(6-O-toluenesulfonyl-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

: 1384424-13-8
1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 48 h / 100 °C

2: water; triphenylphosphine / tetrahydrofuran / 48 h / 20 °C

3: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / methanol; dichloromethane / 16 h / 20 °C

With 4-methyl-morpholine; sodium azide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Staudinger reaction;
DOI:10.1002/cbic.201200004

Reference yield:

: 1384424-11-6
1-O-(6-azido-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

: 1384424-13-8
1-O-(6-(4-nitrophenylacetamido)-6-deoxy-α-D-galactopyranosyl)-2-(11-(3,4-difluorophenyl)undecanoyl)amino-D-ribo-1,3,4-octadecanetriol

Guidance literature:: Multi-step reaction with 2 steps

1: water; triphenylphosphine / tetrahydrofuran / 48 h / 20 °C

2: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / methanol; dichloromethane / 16 h / 20 °C

With 4-methyl-morpholine; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1: Staudinger reaction;
DOI:10.1002/cbic.201200004