2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

Base Information

• Chemical Name: 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine
• CAS No.: 334706-50-2
• Molecular Formula: C₁₇H₂₄BrNO
• Molecular Weight: 338.288
• Mol file: 334706-50-2.mol

Synonyms:2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

Chemical Property of 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

There total 1 articles about 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(-)-aminomenthol (55179-51-6) + ortho-bromobenzaldehyde (6630-33-7) → 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-50-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0040-4020(01)00274-5

Reference yield: 98.0%

2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-50-2) → N-(o-bromobenzyl)-8-aminomenthol (203190-43-6)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(01)00274-5

Reference yield: 92.0%

Cinnamyl bromide (4392-24-9) + 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-50-2) → (2S,7R,9R,10S)-2-(o-bromophenyl)-3-cinnamyl-4,4,7-trimethyl-octahydro-2H-1,3-benzoxazine (350508-47-3)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1021/ja002864q

upstream raw materials:

(-)-aminomenthol

ortho-bromobenzaldehyde

Downstream raw materials:

N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

(2S,7R,9R,10S)-2-(o-bromophenyl)-3-crotyl-4,4,7-trimethyl-octahydro-2H-1,3-benzoxazine

N-allyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

(2S,7R,9R,10S)-2-(o-bromophenyl)-3-cinnamyl-4,4,7-trimethyl-octahydro-2H-1,3-benzoxazine