N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

Base Information

• Chemical Name: N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine
• CAS No.: 334706-53-5
• Molecular Formula: C₂₁H₃₀BrNO
• Molecular Weight: 392.379

Synonyms:N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

Chemical Property of N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

Chemical Property:

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Technology Process of N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

There total 3 articles about N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E/Z)-crotyl bromide (4784-77-4,29576-14-5,39616-19-8) + 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-50-2) → N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-53-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1016/S0040-4020(01)00274-5

Reference yield:

(-)-aminomenthol (55179-51-6) → N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / CH₂Cl₂ / 4 h / 20 °C

2: 80 percent / potassium carbonate / acetonitrile / Heating

With potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(01)00274-5

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (334706-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / CH₂Cl₂ / 4 h / 20 °C

2: 80 percent / potassium carbonate / acetonitrile / Heating

With potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(01)00274-5

upstream raw materials:

(E/Z)-crotyl bromide

2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine

(-)-aminomenthol

ortho-bromobenzaldehyde

Downstream raw materials:

(1R,2S,5R)-2-[1-((R)-4-Ethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol

(R)-4-ethyl-1,2,3,4-tetrahydroisoquinoline

(5R,7aS,10R,11aR,12aS)-5-Ethyl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene

(2S,4aS,7R,8aR)-4,4,7-trimethyl-2-phenyl-octahydro-benz[e][1,3]oxazine

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