Boc-(L)-Ala-Δbut-OMe

Base Information

• Chemical Name: Boc-(L)-Ala-Δbut-OMe
• CAS No.: 87363-79-9
• Molecular Formula: C₁₉H₂₆N₂O₅
• Molecular Weight: 362.426
• Mol file: 87363-79-9.mol

Synonyms:Boc-(L)-Ala-Δbut-OMe

Chemical Property of Boc-(L)-Ala-Δbut-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-(L)-Ala-Δbut-OMe

There total 4 articles about Boc-(L)-Ala-Δbut-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C22H29Cl3N2O8 → Boc-(L)-Ala-Δbut-OMe (87363-79-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 28 ℃; for 0.166667h;

DOI:10.1002/psc.1210

Reference yield: 56.0%

Boc-L-phenylalanine-L-threonine methyl ester (500220-28-0) → Boc-(L)-Ala-Δbut-OMe (87363-79-9) + (E)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-but-2-enoic acid methyl ester (530151-17-8)

Guidance literature:

With Martins sulfurane; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4039(02)02179-2

Reference yield: 20.0%

N-Boc-L-Phe-L-Thr-O-Me (73763-45-8) → (1S,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-acetamid (126188-49-6) + Boc-(L)-Ala-Δbut-OMe (87363-79-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 1h;

upstream raw materials:

methanol

N-tert-butoxycarbonyl-L-phenylalanine

N-carboxy 2-amino-2-butenoic acid anhydride

N-Boc-L-Phe-L-Thr-O-Me

Downstream raw materials:

Boc-L-Phe-Z-ΔAbu(β-I)-OMe