2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone

Base Information

• Chemical Name: 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone
• CAS No.: 74532-57-3
• Molecular Formula: C₂₅H₄₀O₃SSi
• Molecular Weight: 448.742
• Mol file: 74532-57-3.mol

Synonyms:2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone

Chemical Property of 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone

There total 4 articles about 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromocyclododecan-1-one (31236-94-9) → 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone (74532-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (C₆H₁₃)4NBr / dimethylformamide / 1.5 h / 120 °C

2: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

With (C₆H₁₃)4NBr; sodium hydride; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/ja00537a049

Reference yield:

2-(trimethylsilylmethyl)prop-2-en-1-ol (81302-80-9) → 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone (74532-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

With sodium hydride; triethylamine; sodium iodide; In dichloromethane;

DOI:10.1021/ja00537a049

Reference yield:

cyclododecanone (830-13-7) → 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclododecanone (74532-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂ / CHCl₃ / 1.5 h / Ambient temperature

2: (C₆H₁₃)4NBr / dimethylformamide / 1.5 h / 120 °C

3: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

With (C₆H₁₃)4NBr; bromine; sodium hydride; sodium iodide; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja00537a049

upstream raw materials:

2-benzenesulfonylcyclododecanone

3-trimethylsilyl-2-(methylsulphonyloxymethyl)prop-1-ene

2-bromocyclododecan-1-one

2-(trimethylsilylmethyl)prop-2-en-1-ol

Downstream raw materials:

3-Methyl-spiro[4.10]pentadec-2-en-1-one

13a-Benzenesulfonyl-2-methylene-tetradecahydro-cyclopentacyclododecen-3a-ol