N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

Base Information

Chemical Name:N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol
CAS No.:89103-67-3
Molecular Formula:C₂₇H₄₆N₂O₅
Molecular Weight:478.673
Hs Code.:

Synonyms:N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

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Chemical Property of N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

Chemical Property:

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Technology Process of N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

There total 2 articles about N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33294-55-2
(S)-2-(tert-butoxycarbonylamino)-3-methylbutanoic anhydride

: (2R,5S)-5-Amino-1-benzyloxy-2,7-dimethyl-octan-4-ol; hydrochloride

: 89028-20-6
N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4R,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

: 89103-67-3
N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 6h; Title compound not separated from byproducts;

Reference yield:

: 89028-19-3,89065-03-2,106032-63-7
N-(tert-butoxycarbonyl)-(2R,4RS,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

: 89103-67-3
N-<(tert-butoxycarbonyl)-L-valyl>-(2R,4S,5S)-5-amino-1-(benzyloxy)-2,7-dimethyloctan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane / 0.5 h

2: 1.) NEt₃, 2.) DCC / CH₂Cl₂; dimethylformamide / 6 h / 0 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;