BOC-VAL-ANHYDRIDE

Base Information

• Chemical Name: BOC-VAL-ANHYDRIDE
• CAS No.: 33294-55-2
• Molecular Formula: C20H36 N2 O7
• Molecular Weight: 416.515
• Hs Code.: 2924199090
• Mol file: 33294-55-2.mol

Synonyms:L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-, anhydride (9CI); Valine, N-carboxy-,1,1'-anhydride, di-tert-butyl ester, L- (8CI)

Chemical Property of BOC-VAL-ANHYDRIDE

Chemical Property:

• PSA: 120.03000
• LogP: 3.93660

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-VAL-ANHYDRIDE

There total 9 articles about BOC-VAL-ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

t-Boc-L-valine (13734-41-3) + 2-tert-butoxy-4-isopropyl-L-5(4H)-oxazolone (77867-79-9) → (S)-2-(tert-butoxycarbonylamino)-3-methylbutanoic anhydride (33294-55-2)

Guidance literature:

In dichloromethane; for 0.25h;

Reference yield: 20.0%

t-Boc-L-valine (13734-41-3) → (S)-2-(tert-butoxycarbonylamino)-3-methylbutanoic anhydride (33294-55-2) + 2-tert-butoxy-4-isopropyl-L-5(4H)-oxazolone (77867-79-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield: 12.0%

N-Boc-(S/R)-valine (13734-41-3,22838-58-0,54895-12-4) + dicyclohexyl-carbodiimide (538-75-0) → N-t-butoxycarbonylvaline anhydride (33294-55-2,81943-33-1) + N-(tert-Butyloxycarbonyl-valin)-dicyclohexylharnstoff (5042-75-1) + 1,3-Dicyclohexylurea (2387-23-7) + 2-t-butoxy-4-isopropyloxazol-5(4H)-one (77867-79-9)

Guidance literature:

for 24h; Product distribution;

DOI:10.1039/c39810001225

upstream raw materials:

N-Boc-(S/R)-valine

dicyclohexyl-carbodiimide

t-Boc-L-valine

L-valine methylester hydrochloride

Downstream raw materials:

N-(tert-Butyloxycarbonyl-valin)-dicyclohexylharnstoff

2-t-butoxy-4-isopropyloxazol-5(4H)-one

N^α-t-butyloxycarbonyl-L-valyl-L-asparginyl-L-phenylalanyl methyl ester

N-(tert-butoxycarbonyl)-L-valyl-4(S)-amino-3(S)-hydroxy-5-phenylpentanoyl-L-alanyl isoamylamide