6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone

Base Information

• Chemical Name: 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone
• CAS No.: 77931-04-5
• Molecular Formula: C₁₈H₁₄Br₂N₂O₃S
• Molecular Weight: 498.195
• Mol file: 77931-04-5.mol

Synonyms:6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone

Chemical Property of 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone

There total 3 articles about 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

6,8-dibromo-2-thio-3-benzylquinazolin-2,4(1H,3H)-dione (18730-39-7) + L-2-chloropropionic acid sodium salt (16987-02-3) → 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone (77931-04-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 15 ℃; for 8h;

Reference yield:

Benzyl isothiocyanate (622-78-6) → 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone (77931-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / ethanol

2: 50 percent / NaOH / ethanol / 8 h / 15 °C

With sodium hydroxide; In ethanol;

Reference yield:

2-amino-3,5-dibromobenzoic acid (609-85-8) → 6,8-dibromo-3-benzyl-2-(α-methylcarboxymethylthio)-4(3H)-quinazolinone (77931-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / ethanol

2: 50 percent / NaOH / ethanol / 8 h / 15 °C

With sodium hydroxide; In ethanol;

upstream raw materials:

6,8-dibromo-2-thio-3-benzylquinazolin-2,4(1H,3H)-dione

L-2-chloropropionic acid sodium salt

Benzyl isothiocyanate

2-amino-3,5-dibromobenzoic acid

Downstream raw materials:

3-benzyl-6,8-dibromo-1H-quinazoline-2,4-dione