N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine

Base Information

• Chemical Name: N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine
• CAS No.: 1200798-06-6
• Molecular Formula: C₁₃H₁₇F₃N₂O₃S
• Molecular Weight: 338.351
• Mol file: 1200798-06-6.mol

Synonyms:N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine

Chemical Property of N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine

There total 6 articles about N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1200797-99-4) → N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1200798-06-6)

Guidance literature:

formaldehyd; O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 12h;

Reference yield:

tert-butyl 4-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)piperidine-1-carboxylate (143539-99-5) → N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1200798-06-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 0.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17 h / 20 °C

3.1: hydrazine hydrate / ethanol / 0.5 h / 20 °C

4.1: 1,2-dichloro-ethane / 3 h / 20 °C

4.2: 12 h / 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-ol (1022288-59-0) → N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine (1200798-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: hydrazine hydrate / ethanol / 0.5 h / 20 °C

3.1: 1,2-dichloro-ethane / 3 h / 20 °C

3.2: 12 h / 20 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; 1.1: Mitsunobu reaction;

upstream raw materials:

formaldehyd

O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine

tert-butyl 4-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)piperidine-1-carboxylate

1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-ol

Downstream raw materials:

3-(4-fluorophenyl)-1-methyl-1-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)urea