1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

Base Information

Chemical Name:1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol
CAS No.:1438434-92-4
Molecular Formula:C₂₀H₁₈F₃N₇O
Molecular Weight:429.404
Hs Code.:

Synonyms:1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

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Chemical Property of 1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

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Technology Process of 1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

There total 4 articles about 1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₁₇H₁₂ClF₃N₆

: 18621-18-6
azetion-3-ol hydrochloride

: 1438434-92-4
1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

Guidance literature:: With triethylamine; In dichloromethane; Inert atmosphere;
DOI:10.1021/jm400312y

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1438434-92-4
1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / ethanol; water / 0.33 h / 70 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: trichlorophosphate; 1,2,4-Triazole; triethylamine / acetonitrile / 12 h / 80 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / Inert atmosphere

With 1,2,4-Triazole; potassium phosphate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1021/jm400312y

Reference yield:

: 1394034-64-0
5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-7-methylimidazo-[5,1-f ][1,2,4]triazin-4(3H)-one

: 1438434-92-4
1-(7-methyl-5-{1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}imidazo[5,1-f][1,2,4]triazin-4-yl)azetidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / ethanol; water / 0.33 h / 70 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: trichlorophosphate; 1,2,4-Triazole; triethylamine / acetonitrile / 12 h / 80 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / Inert atmosphere

With 1,2,4-Triazole; potassium phosphate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1021/jm400312y