7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

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Chemical Name:7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one
CAS No.:1394034-73-1
Molecular Formula:C₁₇H₁₃F₃N₆O
Molecular Weight:374.325
Hs Code.:

Synonyms:7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

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Chemical Property of 7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

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Technology Process of 7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

There total 6 articles about 7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1394034-64-0
5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-7-methylimidazo-[5,1-f ][1,2,4]triazin-4(3H)-one

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1394034-73-1
7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In water; isopropyl alcohol; at 20 ℃; for 3.16h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.7b01466

Reference yield:

: 1394034-59-3
2-bromo-1-(5-bromo-1-methyl-1H-pyrazol-4-yl)ethanone

: 1394034-73-1
7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; 2-methyltetrahydrofuran / 2.5 h / Reflux

2: dichloromethane / 2.5 h

3: iso-butanol / 24 h / 20 - 100 °C

4: 1,4-dioxane / 6.25 h / 20 - 50 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 18.55 h / 100 - 130 °C / Microwave irradiation

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; iso-butanol;

Reference yield:

: 1394034-60-6
tert-butyl [4-(5-bromo-1-methyl-1H-pyrazol-4-yl)-2-methyl-1H-imidazol-1-yl]carbamate

: 1394034-73-1
7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 2.5 h

2: iso-butanol / 24 h / 20 - 100 °C

3: 1,4-dioxane / 6.25 h / 20 - 50 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 18.55 h / 100 - 130 °C / Microwave irradiation

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; iso-butanol;